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KMID : 1094020150320060486
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Journal of Veterinary Clinics
2015 Volume.32 No. 6 p.486 ~ p.490
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Clinical Usefulness of Contrast Echocardiography : Dose Effect for Left Ventricle Visualization in Dogs
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Shin Chang-Ho
Hwang Tae-Sung
Yoon Young-Min
Jung Dong-In
Yeon Seong-Chan
Lee Hee-Chun
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Abstract
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Two-demensional echocardiography is routinely used for evaluation of cardiac function. Visualization of theendocardial border is essential for the assessment of global and regional left ventricular with cardiac disease. SonoVueTMis a microbubble contrast agent that consists of sulfur hexafluoride-filled microbubbles in a phospholipid shell. Therewere many studies about contrast echocardiographic examination using SonoVueTM contrast agent, and various dosesof SonoVueTM were used. To our knowledge, in published veterinary medicine, there was not reported for diagnosticefficient dose of SonoVueTM to evaluate contrast enhanced left ventricular endocardial border delineation (LVEBD). The purpose of this study is to compare the visualization time of LVEBD and find efficient dose of SonoVueTM forusing various doses in dogs. Ten healthy Beagles were recruited to the study. Three different doses (0.03 ml/kg, 0.05 ml/kg and 0.1 ml/kg) of SonoVueTM were injected. Endocardial segments were assigned based on previously establishedmethodology, where by the four-chamber views of the LV were divided into 6 segments. In this study, Contrastenhancement of the LVEBD after each injection was evaluated visually at the time point of overall contrast enhancement(Segmental scoring 5+) in the LV by three investigators in a blind manner. Statistical analysis was performed withSPSS version 14.0. All data were analyzed using one-way ANOVA, the multiple comparison Scheffe test. When datafor the three offsite readers were combined, mean durations of useful contrast were 3.54 (± 2.14), 6.15 (± 2.61), and24.39 (± 11.10) seconds for the 0.03 ml/kg, 0.05 ml/kg, and 0.1 ml/kg SonoVueTM doses, respectively. After injectionof contrast agent, there were no significant change in side effects such as urticaria, angioedema, hypersensitivityreactions, and digestive system disorders. This study suggests that efficient dose of SonoVueTM contrast agent forimprovement of the left ventricle visualization is 0.1 ml/kg. The duration of useful enhancement of LVEBD and thereproducibility were also the highest at the 0.1 ml/kg dosage.
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KEYWORD
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Ultrasound Contrast Agent, Left Ventricle Visualization, Dog
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